New Chemical Compounds Provide Protection Against SARS-CoV-2

April 28, 2023, 3:18 p.m.

The interdisciplinary team at CERTH has developed two new chemical compounds that protect against SARS-CoV-2, the virus responsible for Covid-19. By screening a library of 500,000 chemical substances, they identified compounds that inhibit the interaction between the virus's spike protein and the human ACE2 receptor. These compounds demonstrated protective activity against SARS-CoV-2 and were not affected by mutations in the spike protein. The team plans to utilize these compounds for developing new drugs to combat SARS-CoV-2 and other ACE2-dependent viruses. A patent application has been filed to protect their research findings. The team comprised researchers from EKETA, the National Hellenic Research Foundation, Democritus University of Thrace, and National and Kapodistrian University of Athens, along with their collaborators.

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